ON THE 9TH DAY OF CHRISTMAS, ABC FAMILY WILL BRING "THE MISTLE-TONES," A NEW ORIGINAL CHRISTMAS MUSICAL STARRING TORI SPELLING AND TIA MOWRY ON SUNDAY, DECEMBER 9
"The Mistle-Tones" Soundtrack to be Released November 18th
Burbank, CA (October 25, 2012) - ABC Family will premiere "The Mistle-Tones," an all new original musical starring Tori Spelling ("Tori & Dean: Home Sweet Hollywood") and Tia Mowry ("The Game") on Sunday, December 9 (8:00-10:00 PM ET/PT). The movie will air as part of the network's annual "25 Days of Christmas" programming event.
In "The Mistle-Tones," Holly (Tia Mowry), blessed with an amazing singing voice, is all set to audition for the newly vacated spot in a legendary local Christmas group which was founded by her late mother years ago. Shocked and upset when the slot goes to the barely talented best friend of the group's leader, Marci (Tori Spelling), Holly sets out to create her own musical group, The Mistle-Tones. After challenging their rivals to a sing-off on Christmas Eve, Holly finds herself on a journey to the real meaning of Christmas--with some new friends and a new love thrown in for good measure. The film also stars Jonathan Patrick Moore, Reginald VelJohnson, Tammy Townsend, Andy Gala, Megan Kathleen Duffy, and Jason Rogel. "The Mistle-Tones" is executive produced by Maggie Malina ("Single Ladies"), from a script by Jed Elinoff & Scott Thomas ("My Super Psycho Sweet 16"), and directed by Paul Hoen ("Camp Rock 2: The Final Jam").
To make the holiday a little brighter, ABC Family will release an accompanying "The Mistle-Tones" movie soundtrack on Sunday, November 18. Featuring nine songs from the movie sung by the cast, the soundtrack will be available exclusively on Itunes.
Part of the Disney/ABC Television Group, ABC Family is distributed in over 97 million homes. ABC Family features programming reflecting today's families, entertaining and connecting with adults through relatable programming about today's relationships - told with a mix of diversity, passion, humor and heart. ABC Family's programming is a combination of network defining original series and original movies, quality acquired series and blockbuster theatricals. Emmy(R) Award-winning ABCFamily.com provides a variety of interactive entertainment and community features, from rich, fan-centric programming - including blogs, viewing parties, webisodes, full episodes of the network's hit programming, along with sneak peek exclusive previews and behind-the-scenes clips. ABC Family is also the destination for annual Holiday events with "13 Nights of Halloween" and "25 Days of Christmas." ABC Family. A New Kind of Family.
A clearer picture of how assassin bugs evolvedPublic release date: 25-Oct-2012 [ | E-mail | Share ]
Contact: Iqbal Pittalwala iqbal@ucr.edu 951-827-6050 University of California - Riverside
UC Riverside entomologists reconstruct the evolutionary history of assassin bugs; new work fine-tunes the Tree of Life
RIVERSIDE, Calif. Assassin bugs, so named because these insects lie in ambush for prey that they attack with speed and precision, are found all over the world. Nearly 140 species of these bugs are blood-sucking; because they can bite humans around the mouth, they are also called kissing bugs. All kissing bugs can spread Chagas disease, a neglected tropical disease that imposes an economic burden on society.
Surprising, then, that scientists' understanding of the evolutionary history of assassin bugs is riddled with difficulty. The data are incomplete. Fossils, which exist for only a few groups of assassin bugs, are young, providing only patchy information on how these bugs evolved.
Now entomologists at the University of California, Riverside have produced a clearer snapshot of the entire evolutionary history of assassin bugs by integrating molecular, paleontological, behavioral and ecological data into their analyses. The result of their painstaking work is a new phylogeny the representation of the evolutionary relationships between species for assassin bugs. It includes the most number of assassin bugs to date and represents the most number of subfamilies.
"We can now zoom in on specific groups within the phylogeny to examine specific aspects of the evolution of that group," said Christiane Weirauch, an associate professor of entomology who reconstructed the assassin bug phylogeny with her Ph.D. graduate student Wei Song Hwang. "Our phylogeny significantly improves our knowledge about relationships within assassin bugs and will guide future research work in understanding how some of the interesting prey specialization behaviors and prey capture techniques have evolved."
Study results appeared last month in PLoS ONE.
"One significant improvement is the addition of several assassin bug species from the subfamily Reduviinae, the second largest subfamily of assassin bugs," said Hwang, the first author of the research paper. "Previous phylogenies have a very limited representation of Reduviinae, which means the overall interpretation of the phylogeny is of limited value."
Assassin bugs are estimated to have originated during the Middle Jurassic (~178 million years ago), making them a relatively old group of insects. They diversified significantly in the Late Cretaceous (~97 million years ago); indeed, nearly 90 percent of the existing species diversity we see today in assassin bugs started to diversify from this time onwards. The cause of this diversification remains unknown.
Blood-feeding kissing bugs
Weirauch and Hwang also determined that kissing bugs originated just 27-32 million years ago, the previous estimate being 107 million years ago. Mostly found in Central and South America, these bugs have evolved to feed on vertebrate blood lizards, birds, opossums, armadillos, bats, etc., and humans and can be found in diverse environments, from the Sonoran desert to the Amazon rainforest.
"The previous estimate of 107 million years ago linked the diversification of kissing bugs with the splitting of South America from Antarctica and provided a longer time-span for kissing bugs to speciate and spread across the continent and adapt," Hwang said. "Our research shows that this is not the case. By including more data and improving estimation methods, our younger estimate of 27-32 million years ago matches the time when the hosts, mainly mammals and birds, were diversifying at a rapid rate in South America."
The researchers caution that as natural environments get altered, more kissing bugs may be seen adapting to new environments and hosts rather than going extinct.
"The colonization of human settlements by wild kissing bugs we are witnessing now is thus likely to increase in intensity as more natural environments are replaced by human activities," Hwang said.
With their comprehensive sampling of assassin bugs and large molecular dataset, Weirauch and Hwang also show that the blood-feeding kissing bugs either have a single origin or two separate but close origins. Until now, the possibility of two separate but close origins of kissing bugs had not been hypothesized nor demonstrated.
"The possibility that there are two separate lineages implies that there will be shared traits among the lineages, but also slight differences we need to be aware of when developing different preventative strategies," Hwang explained. "A single origin, on the other hand, means we can expect common traits shared among all kissing bugs that can be targeted for control or monitoring."
Building the Tree of Life
The current research is part of the scientific endeavor to reconstruct the entire Tree of Life the biological concept that all living organisms are related and can be traced back to a single ancestor representing the origin of life on Earth.
"Reconstructing a phylogeny, a framework from which we can infer the evolutionary history of any group of organisms, is thus the first step towards understanding how life evolved, how different species relate to one another, how specific traits evolved over time, and why biodiversity occurs the way it does today," Weirauch said.
###
The study was financially supported by the Partnership for Enhancing Expertise in Taxonomy (PEET) program of the National Science Foundation, the UCR Department of Entomology, a UCR Graduate Division Dissertation Year Program Award and an American Museum of Natural History Collection Study Grant.
The University of California, Riverside is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment has exceeded 20,500 students. The campus will open a medical school in 2013 and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Center. The campus has an annual statewide economic impact of more than $1 billion. A broadcast studio with fiber cable to the AT&T Hollywood hub is available for live or taped interviews. UCR also has ISDN for radio interviews. To learn more, call (951) UCR-NEWS.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
A clearer picture of how assassin bugs evolvedPublic release date: 25-Oct-2012 [ | E-mail | Share ]
Contact: Iqbal Pittalwala iqbal@ucr.edu 951-827-6050 University of California - Riverside
UC Riverside entomologists reconstruct the evolutionary history of assassin bugs; new work fine-tunes the Tree of Life
RIVERSIDE, Calif. Assassin bugs, so named because these insects lie in ambush for prey that they attack with speed and precision, are found all over the world. Nearly 140 species of these bugs are blood-sucking; because they can bite humans around the mouth, they are also called kissing bugs. All kissing bugs can spread Chagas disease, a neglected tropical disease that imposes an economic burden on society.
Surprising, then, that scientists' understanding of the evolutionary history of assassin bugs is riddled with difficulty. The data are incomplete. Fossils, which exist for only a few groups of assassin bugs, are young, providing only patchy information on how these bugs evolved.
Now entomologists at the University of California, Riverside have produced a clearer snapshot of the entire evolutionary history of assassin bugs by integrating molecular, paleontological, behavioral and ecological data into their analyses. The result of their painstaking work is a new phylogeny the representation of the evolutionary relationships between species for assassin bugs. It includes the most number of assassin bugs to date and represents the most number of subfamilies.
"We can now zoom in on specific groups within the phylogeny to examine specific aspects of the evolution of that group," said Christiane Weirauch, an associate professor of entomology who reconstructed the assassin bug phylogeny with her Ph.D. graduate student Wei Song Hwang. "Our phylogeny significantly improves our knowledge about relationships within assassin bugs and will guide future research work in understanding how some of the interesting prey specialization behaviors and prey capture techniques have evolved."
Study results appeared last month in PLoS ONE.
"One significant improvement is the addition of several assassin bug species from the subfamily Reduviinae, the second largest subfamily of assassin bugs," said Hwang, the first author of the research paper. "Previous phylogenies have a very limited representation of Reduviinae, which means the overall interpretation of the phylogeny is of limited value."
Assassin bugs are estimated to have originated during the Middle Jurassic (~178 million years ago), making them a relatively old group of insects. They diversified significantly in the Late Cretaceous (~97 million years ago); indeed, nearly 90 percent of the existing species diversity we see today in assassin bugs started to diversify from this time onwards. The cause of this diversification remains unknown.
Blood-feeding kissing bugs
Weirauch and Hwang also determined that kissing bugs originated just 27-32 million years ago, the previous estimate being 107 million years ago. Mostly found in Central and South America, these bugs have evolved to feed on vertebrate blood lizards, birds, opossums, armadillos, bats, etc., and humans and can be found in diverse environments, from the Sonoran desert to the Amazon rainforest.
"The previous estimate of 107 million years ago linked the diversification of kissing bugs with the splitting of South America from Antarctica and provided a longer time-span for kissing bugs to speciate and spread across the continent and adapt," Hwang said. "Our research shows that this is not the case. By including more data and improving estimation methods, our younger estimate of 27-32 million years ago matches the time when the hosts, mainly mammals and birds, were diversifying at a rapid rate in South America."
The researchers caution that as natural environments get altered, more kissing bugs may be seen adapting to new environments and hosts rather than going extinct.
"The colonization of human settlements by wild kissing bugs we are witnessing now is thus likely to increase in intensity as more natural environments are replaced by human activities," Hwang said.
With their comprehensive sampling of assassin bugs and large molecular dataset, Weirauch and Hwang also show that the blood-feeding kissing bugs either have a single origin or two separate but close origins. Until now, the possibility of two separate but close origins of kissing bugs had not been hypothesized nor demonstrated.
"The possibility that there are two separate lineages implies that there will be shared traits among the lineages, but also slight differences we need to be aware of when developing different preventative strategies," Hwang explained. "A single origin, on the other hand, means we can expect common traits shared among all kissing bugs that can be targeted for control or monitoring."
Building the Tree of Life
The current research is part of the scientific endeavor to reconstruct the entire Tree of Life the biological concept that all living organisms are related and can be traced back to a single ancestor representing the origin of life on Earth.
"Reconstructing a phylogeny, a framework from which we can infer the evolutionary history of any group of organisms, is thus the first step towards understanding how life evolved, how different species relate to one another, how specific traits evolved over time, and why biodiversity occurs the way it does today," Weirauch said.
###
The study was financially supported by the Partnership for Enhancing Expertise in Taxonomy (PEET) program of the National Science Foundation, the UCR Department of Entomology, a UCR Graduate Division Dissertation Year Program Award and an American Museum of Natural History Collection Study Grant.
The University of California, Riverside is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment has exceeded 20,500 students. The campus will open a medical school in 2013 and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Center. The campus has an annual statewide economic impact of more than $1 billion. A broadcast studio with fiber cable to the AT&T Hollywood hub is available for live or taped interviews. UCR also has ISDN for radio interviews. To learn more, call (951) UCR-NEWS.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
A trusted Ugandan colleague called one afternoon to share the news that he had found someone whom I might hire as a field assistant. Jack and I met with our colleague and the prospective hire, Nick, an hour later in town. Nick is a young forestry college graduate with knowledge of local trees and an eagerness that was immediately evident. I offered him the job and our work began soon after.
A chimpanzee nest. Photo: Maureen McCarthy.
Upon venturing into the field a couple days later, we found our first and most familiar sign of chimpanzee presence: nests. For the most part, chimpanzees build a new nest each night. These large, leafy beds are constructed by bending branches into a rounded, cushiony shape. The interwoven leaves and branches create a kind of mattress high in the trees.
Nest construction is a skill that takes some time to learn, so young chimpanzees sleep in their mothers? nests until they are old enough to reliably build their own. Nests of the same age are often found together, evidence that a party, or small group, of chimpanzees slept near each other.
Finding nests is vital to my research project. Nests provide crucial information regarding where the chimpanzees have been spending their time. This is important because the chimpanzees I study are unhabituated, meaning they are not accustomed to researchers following them closely. Unhabituated chimpanzees typically flee when people come near, as is the case with my study subjects.
For this reason, we must rely primarily on indirect evidence rather than direct observations to better understand their behavior patterns. Luckily, the chimpanzees leave ample clues for us. After we find their nests, we often encounter a second critical clue: their dung. Chimpanzee dung can provide a wealth of information. It can provide insights into what the chimpanzees are eating, how long ago they?ve been in a certain area, and much more. My study relies on these little treasure troves to provide chimpanzee DNA. I will later analyze the DNA to answer various questions about the genetics and behavior of these chimpanzees.
The view from inside a chimpanzee nest. Photo: Jack Lester.
I won?t lie. Collecting chimpanzee dung doesn?t quite fit the romantic, Jane Goodall-in-khaki-shorts image of primatology research that I held some years ago. I remember when my first primate behavior professor, Michele Goldsmith, described studying mountain gorillas in Uganda. As she explained it, seeing gorillas was all well and good, but finding their dung was the real thrill. Like me, she relied on dung samples to provide critical data for her research. Though I knew she was joking a bit, I also couldn?t imagine how finding dung could be so exciting. Now I get it. The highlight of my day often comes when I stumble upon a fresh pile of chimpanzee dung.
Chimpanzee mother and infant. Photo: Jack Lester.
Nick listens patiently as I excitedly wax on about the intricacies of poo and demonstrate proper collection technique, then sift through remnants just to see what fascinating discoveries might await us inside our gooey gift from the chimpanzees. I?m certain he must think we?re a bit crazy, especially because direct observations of the chimpanzees have been scarce so far.
Scarce?that is?until yesterday, when we were fortunate enough to have both ample chimpanzee observations and fresh samples to collect. Though we maintained a long distance from the chimpanzees so as not to disturb them, we watched them groom and feed for some time before entering an area they had passed through to see what they left behind. In the process, we found several nests, dung samples, and feeding sites. Data-rich days like these make up for the occasional long days of walking with little or no evidence that chimpanzees aren?t just some figment of our imaginations. For now, I?ll remain satisfied that they exist while continuing to wonder about the many unresolved mysteries of their fascinating lives in these small islands of forest.
Previously in this series:
Chimps in Uganda: Two weeks and counting?. Chimps in Uganda: ?These are a few of my favorite things? Chimps in Uganda: Home Sweet Home Chimps in Uganda: Bustling Kampala and Unwanted Houseguests
Elevator pitches are a great way to condense a complex idea into a small amount of time so you can get the idea in front of someone who matters. Author Seth Godin recommends you pitch for a meeting, not the idea itself.
Essentially, the idea is to use that brief amount of time when you're in front of the powers-that-be to get a meeting so you can really pitch your project in full. Godin explains:
The best elevator pitch doesn't pitch your project. It pitches the meeting about your project. The best elevator pitch is true, stunning, brief and it leaves the listener eager (no, desperate) to hear the rest of it. It's not a practiced, polished turd of prose that pleases everyone on the board and your marketing team, it's a little fractal of the entire story, something real.
Of course, the elevator pitch isn't exclusive to elevators. It's useful when you need to pitch an idea?any idea?to anyone you want to work with. Godin's suggestion is that when you compress that idea into a two minute overview, the idea only loses a bit in the process. It also makes it a lot easier for someone to say "no." When you pitch the meeting, your ensuring you get the idea in front of people who matter, and it becomes a real conversation as opposed to an announcement.
No one ever bought anything on an elevator | Seth Godin
ScienceDaily (Oct. 17, 2012) ? Imagine navigating through a grocery store with your cell phone. As you turn down the bread aisle, ads and coupons for hot dog buns and English muffins pop up on your screen. The electronics industry would like to make such personal navigators a reality, but, to do so, they need the next generation of microsensors.
Thanks to an ultrasensitive accelerometer -- a type of motion detector -- developed by researchers at the California Institute of Technology (Caltech) and the University of Rochester, this new class of microsensors is a step closer to reality. Beyond consumer electronics, such sensors could help with oil and gas exploration deep within the Earth, could improve the stabilization systems of fighter jets, and could even be used in some biomedical applications where more traditional sensors cannot operate.
Caltech professor of applied physics Oskar Painter and his team describe the new device and its capabilities in an advance online publication of the journal Nature Photonics.
Rather than using an electrical circuit to gauge movements, their accelerometer uses laser light. And despite the device's tiny size, it is an extremely sensitive probe of motion. Thanks to its low mass, it can also operate at a large range of frequencies, meaning that it is sensitive to motions that occur in tens of microseconds, thousands of times faster than the motions that the most sensitive sensors used today can detect.
"The new engineered structures we made show that optical sensors of very high performance are possible, and one can miniaturize them and integrate them so that they could one day be commercialized," says Painter, who is also codirector of Caltech's Kavli Nanoscience Institute.
Although the average person may not notice them, microchip accelerometers are quite common in our daily lives. They are used in vehicle airbag deployment systems, in navigation systems, and in conjunction with other types of sensors in cameras and cell phones. They have successfully moved into commercial use because they can be made very small and at low cost.
Accelerometers work by using a sensitive displacement detector to measure the motion of a flexibly mounted mass, called a proof mass. Most commonly, that detector is an electrical circuit. But because laser light is one of the most sensitive ways to measure position, there has been interest in making such a device with an optical readout. For example, projects such as the Laser Interferometer Gravitational-Wave Observatory (LIGO) rely on optical interferometers, which use laser light reflecting off mirrors separated by kilometers of distance to sensitively measure relative motion of the end mirrors. Lasers can have very little intrinsic noise -- meaning that their intensity fluctuates little -- and are typically limited by the quantum properties of light itself, so they make it much easier to detect very small movements.
People have tried, with limited success, to make miniature versions of these large-scale interferometers. One stumbling block for miniaturization has been that, in general, the larger the proof mass, the larger the resulting motion when the sensor is accelerated. So it is typically easier to detect accelerations with larger sensors. Also, when dealing with light rather than electrons -- as in optical accelerometers -- it is a challenge to integrate all the components (the lasers, detectors, and interferometer) into a micropackage.
"What our work really shows is that we can take a silicon microchip and scale this concept of a large-scale optical interferometer all the way down to the nanoscale," Painter says. "The key is this little optical cavity we engineered to read out the motion."
The optical cavity is only about 20 microns (millionths of a meter) long, a single micron wide, and a few tenths of a micron thick. It consists of two silicon nanobeams, situated like the two sides of a zipper, with one side attached to the proof mass. When laser light enters the system, the nanobeams act like a "light pipe," guiding the light into an area where it bounces back and forth between holes in the nanobeams. When the tethered proof mass moves, it changes the gap between the two nanobeams, resulting in a change in the intensity of the laser light being reflected out of the system. The reflected laser signal is in fact tremendously sensitive to the motion of the proof mass, with displacements as small as a few femtometers (roughly the diameter of a proton) being probed on the timescale of a second.
It turns out that because the cavity and proof mass are so small, the light bouncing back and forth in the system pushes the proof mass -- and in a special way: when the proof mass moves away, the light helps push it further, and when the proof mass moves closer, the light pulls it in. In short, the laser light softens and damps the proof mass's motion.
"Most sensors are completely limited by thermal noise, or mechanical vibrations -- they jiggle around at room temperature, and applied accelerations get lost in that noise," Painter says. "In our device, the light applies a force that tends to reduce the thermal motion, cooling the system." This cooling -- down to a temperature of three kelvins (about -270?C) in the current devices -- increases the range of accelerations that the device can measure, making it capable of measuring both extremely small and extremely large accelerations.
"We made a very sensitive sensor that, at the same time, can also measure very large accelerations, which is valuable in many applications," Painter says.
The team envisions its optical accelerometers becoming integrated with lasers and detectors in silicon microchips. Microelectronics companies have been working for the past 10 or 15 years to try to integrate lasers and optics into their silicon microelectronics. Painter says that a lot of engineering work still needs to be done to make this happen, but adds that "because of the technological advancements that have been made by these companies, it looks like one can actually start making microversions of these very sensitive optical interferometers."
"Professor Painter's research in this area nicely illustrates how the Engineering and Applied Science faculty at Caltech are working at the edges of fundamental science to invent the technologies of the future," says Ares Rosakis, chair of Caltech's Division of Engineering and Applied Science. "It is very exciting to envision the ways this research might transform the microelectronics industry and our daily lives."
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The above story is reprinted from materials provided by California Institute of Technology. The original article was written by Kimm Fesenmaier.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Alexander G. Krause, Martin Winger, Tim D. Blasius, Qiang Lin, Oskar Painter. A high-resolution microchip optomechanical accelerometer. Nature Photonics, 2012; DOI: 10.1038/nphoton.2012.245
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
(Reuters) - Former Democratic Senator George McGovern, who lost to Richard Nixon in the 1972 presidential election, is "no longer responsive" and is surrounded by family and friends at a hospice center in South Dakota, his family said on Wednesday.
McGovern, 90, was admitted to hospice in Sioux Falls "with a combination of medical conditions, due to age, that have worsened over recent months," his family said in a statement.
"The Senator is no longer responsive. He is surrounded by his loving family and close friends," the statement added.
McGovern served in the Senate for South Dakota from 1963 to 1981. He unsuccessfully challenged Nixon in 1972 on a platform opposing the Vietnam War. He won only 37.5 percent of the popular vote and carried only Massachusetts and the District of Columbia in one of the worst defeats in U.S. history.
The son of a Methodist minister, McGovern flew combat missions over Europe as a B-24 bomber pilot during World War Two, earning the Distinguished Flying Cross.
He was elected to the U.S. House of Representatives in 1956, and re-elected two years later. After McGovern lost a U.S. Senate election in 1960, President John F. Kennedy named him the first director of the Food for Peace Program.
He also ran for president in 1968, had a short-lived bid for the Democratic presidential nomination in 1984, and considered running for president in 1976.
A historian and prolific author, McGovern had been hospitalized several times in the past year after complaining of fatigue and dizziness and after a fall before a scheduled television appearance at the McGovern Library at Dakota Wesleyan University in Mitchell, South Dakota.
On Wednesday, McGovern's family encouraged people to donate to Feeding South Dakota (www.feedingsouthdakota.org) if they planned to offer remembrances of the senator.
(Reporting by David Bailey; Editing by Cynthia Johnston and Peter Cooney)
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Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal Institute of Education, Science and Technology have discovered that an intricate system to repair DNA damage called the "DNA damage response" (DDR) contains previously unknown components, including proteins that could be targeted as sensitizers for chemotherapy. Some of these targets may already have drugs available that have unrecognized uses in cancer therapy, said the researchers.
The study appears in the Sept. 18 issue of Science Signaling.
"A domain called BRCT is frequently present in proteins involved in the DDR network," said study lead author Alvaro N.A. Monteiro, Ph.D., senior member of Moffitt's Cancer Epidemiology Program. "We undertook a systematic analysis of the BRCT domain, a protein module that plays a critical role in the DDR, and found a large network of interacting proteins centered on BRCT-containing proteins. In doing so, we discovered new potential players in the DDR. These new players may constitute potential biomarkers for drug response or targets for treatment."
According to the authors, their data could be used to build a more comprehensive map of the components and interactions involved in the DDR, a system through which proteins detect DNA damage, promote repair and coordinate the cell cycle.
Because defects in the DDR can lead to cancer, the properly functioning network is considered to be a barrier against tumor growth. Chemotherapy regimens exploit weaknesses in the system to kill cancer cells. The new discoveries augment knowledge about the DDR by adding information on the function of specific proteins involved with BRCT-containing proteins.
"Our expectation is that the establishment of the BRCT-network will help identify potential sensitizers of therapy and accelerate the development of new therapeutic strategies," Monteiro said.
###
H. Lee Moffitt Cancer Center & Research Institute: http://www.moffitt.usf.edu
Thanks to H. Lee Moffitt Cancer Center & Research Institute for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
TOKYO (Reuters) - Japan's Nikkei share average gained 1.2 percent on Wednesday after the yen eased to a one-month low against the euro and dollar, and investors took a sunnier view of earnings.
Exporters such as Toyota Motor Corp were given a leg up by a stronger euro as rating agency Moody's stopped short of downgrading Spanish bonds to "junk" status, affirming them at BAA3 in light of the European Central Bank's pledge to buy the bonds if needed.
"The three main factors today are the weaker yen, the fact the Nikkei had hit the bottom of its trading range, and that even companies that cut forecasts are no longer falling," said Shigeo Mito, manager of equity investment at Sumitomo Mitsui Trust.
Hitachi Ltd rose 2.4 percent and was the fourth-most-traded stock on the main board by turnover, two places behind Toyota, as JPMorgan reiterated its "overweight" rating, saying it was likely to meet its 2012 operating profit guidance. However, JPMorgan lowered its own profit outlook for the firm.
The securities sector jumped 2.5 percent, with Nomura Holdings Inc up 3.2 percent after being fined just 300 million yen for leaking client information, and Goldman Sachs raised expectations for the financial sector by doubling revenue and raising its quarterly dividend.
Those gains helped the Nikkei advance 105.24 points percent to 8,806.55, i ts highest close since October 5 and a bove its 14-day moving average at 8,741.81.
"I think that the weakness in the global economy and the expectations of poor earnings were pretty much priced in last week and now we're recovering from that sell-off," said Masayuki Otani, chief market analyst at Securities Japan.
"Consensus cooled down quite a lot and now people are realising it might have gone too far."
A YEN FOR BUYING
The benchmark dropped 3.7 percent last week, its biggest weekly fall since May, after a stream of profit warnings sparked fears of earnings coming in lower than expected, due to a global slowdown, anti-Japanese sentiment and the robust yen.
A strong yen has prompted fears of further cuts to earnings forecasts for exporters as it erodes their revenues garnered abroad once repatriated. Its retreat on Wednesday helped Toyota add 1 percent after the share dropped 3.6 percent last week.
"If the euro and the won continue to get stronger I think sentiment might become a bit more 'risk on'," said Yasuo Sakuma, portfolio manager and executive officer at Bayview Asset Management. The yen struck a 5-1/2 month low against the Korean won on Wednesday.
"This could be a turning point, but it's really too early to tell."
Although a strong yen hurts exporters, some Japanese firms have begun using the robust currency and low borrowing rates to their advantage, snapping up foreign firms at reasonable prices.
This trend was brought into focus by Softbank Corp's $20 billion deal to buy a 70 percent stake in Sprint Nextel Corp , announced this week.
The mobile provider, an index heavyweight, added 5.6 percent on Wednesday to extend Tuesday's 9.6 percent rise on CEO Masayoshi Son's assurance that the move would not dilute Softbank shares. The shares dropped over 20 percent over Friday and Monday on uncertainty about how the deal would be funded.
Also on Wednesday, major trading house Mitsubishi Corp added 0.5 percent after the Nikkei daily said it would buy a 20 percent stake in Indonesian utility Star Energy for $200 million, aiming to double capacity of a geothermal plant in West Java by 2017.
Elsewhere, chipmakers sagged after Intel Corp , the world's largest chipmaker, forecast gross margins for the current quarter below expectations. Ibiden Co Ltd lost 3.8 percent and Advantest Corp fell 2.2 percent.
Yahoo Japan Corp rose 4.6 percent to 30,050 yen, its highest level since March 2011, as investors hoped that the new services it introduced on Tuesday as part of an ongoing tie-up with Facebook Inc , would win more users for its portal and search services, increasing advertising revenue.
The broader Topix added 1.1 percent to 740.78 in strong trade, with volume at 115.8 percent of its average over the past 90 sessions.
This courtroom sketch shows alleged 9/11 mastermind Khalid Sheikh Mohammed as he holds up a piece of paper during a court recess at his hearing on Monday at the U.S. Navy base in Guantanamo Bay, Cuba.
By NBC News' Courtney Kube and wire reports
Updated at 5:20 p.m. ET: The self-professed mastermind of the Sept. 11, 2001, attacks on the United States, which resulted in the deaths of 2,976 people, appeared before a military judge at Guantanamo Bay Naval Base in Cuba on Monday after months of delays due to scheduling conflicts, religious observances, an Internet outage and a tropical storm.
Khalid Sheikh Mohammed shocked some observers by appearing with a long, full beard that had been dyed bright reddish-orange. He appeared before Judge Army Col. James Pohl for the start of a week of pretrial hearings, along with co-defendants Ali Abdul Aziz Ali, a Pakistani; Mustafa Al Hawsawi, a Saudi; and Walid Bin Attash and Ramzi Binalshibh, two men from Yemen.
Unlike their last appearance in court in May, which was disrupted several times by the defendants, the five men sat quietly at the defense table, under the watchful eyes of military guards and several family members of the 9/11 victims, The Associated Press reported. All seemed to be cooperating with their attorneys. Mohammed read legal papers. Two others responded politely to the judge when they were asked questions, according to the AP.
All the defendants wore white robes and turbans, and spoke openly with one another throughout the course of the day.
The men, being prosecuted in a special military tribunal for war-time offenses, are charged with conspiring with al-Qaida, attacking civilians and civilian targets, murder in violation of the laws of war, destruction of property, hijacking and terrorism. All five could face the death penalty if convicted.
Associated Press
Khalid Sheikh Mohammed, the alleged Sept. 11 mastermind, is seen shortly after his capture in Pakistan in this photo taken on March 1, 2003.
The families of people killed in the Sept. 11 attacks were invited to military installations in New Jersey,?Massachusetts, Maryland and New York City?to watch the pretrial hearings?on closed-circuit television, NBCNewYork.com reported.
Getting the terror suspects to this point?has been a years-long?process mired in political and legal arguments over the defendants' rights, the use of evidence that may have been derived through torture, and the proper venue for the proceedings. The actual trial is expected to be at least a year away.
The pretrial hearings this week will cover a series of motions filed by the various defense teams, dealing primarily with secrecy issues and the detainees' rights.
The most controversial issue, which was not taken up by the end of the first day, is a challenge to the government's gag order on any information gained during interrogation of the detainees. The ACLU and more than one dozen news organizations filed a motion to oppose to government's gag order. The government maintains the order is necessary to protect classified intelligence-gathering techniques.
Defendants may skip hearings On Monday, prosecutors and lawyers spent hours arguing the most preliminary of issues, including whether the defendants have to be in court at all, with one attorney saying the hearings may dredge up bad memories of their harsh treatment in CIA detention.
Defense attorney Capt. Michael Schwartz argued that the detainees should not be forced to come to court because the process of forcibly removing them from their cells is traumatic and reminiscent of harsh interrogation techniques.
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Schwartz said that if the court was considering forced cell extraction it had to talk about torture.
"No we don't," the judge said quickly.
"I think we do," Schwartz said.
"I'm telling you I don't think that's relevant in this issue. That's the end of that, move on to something else," Pohl retorted.
But Schwartz persisted, saying he needs to address the issue of torture.
"No you don't," the judge said more forcefully this time, adding that the defense does not have the opportunity to make an argument that he sees as irrelevant.
After a prolonged and heated back-and-forth, the detainees were granted the right to waive their attendence at the hearings at least until jurors are assembled for the actual trial, but they must sign a waiver each day they choose not to attend.
Toward the end of the day, the judge asked each of the five detainees a series of questions to ensure they understand their new rights to waive attendance at their sessions.
Binalshibh answered each of his questions in imperfect?English, veering into a perplexing discussion about escaping from Guantanamo and alleging unfair treatment from his guards.
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When asked whether he understands that the trial could ultimately continue even if he is not present, Binalshibh looked perplexed, saying, "that is a very wide word, can you be concrete?"
"I'm not implying that I think you are going to escape," the judge said, adding that if that were to happen, the trial could continue without him being there.
"Escaping from custody?" Binalshibh asked. "I'm not saying you're going to," the judge said, asking again whether he understands that the trial could continue without him.?Binalshibh seemed to smile as he said, "Yes I do."
Guantamo guards make things 'difficult' He raised concerns about the fact that guards would be sent to bring him to the hearings, though, saying, "dealing with the guard is very difficult. They didn't report everything so correctly. Problems with guards can misreporting all things."
"Some guard when you have problem with them they can make it very difficult for us," he said.
Despite President Obama's vow to shut down Guantanamo Bay, the nation's most expensive prison is undergoing some costly new updates that would allow the facility to remain open for years. NBC's Michael Isikoff reports.
When the judge recommended reporting any problems to his attorney, Binalshibh said, "Where can I call him? There is no time to contact him. Very difficult communication for us."
Mohammed answered his questions through his interpreter. He looked down and answered simply "yes" to every question, until at the end when asked whether he understands he doesn't have to attend the sessions.
"Yes, but I don't think there is any justice in this court," he said through his interpreter.
The court was in session for about five total hours, with several breaks throughout the day. It then adjourned until 9 a.m. ET. Tuesday.
Pohl was also expected to hear requests from news organizations on limiting closed courtrooms for secret sessions and be asked to decide whether the U.S. Constitution governs tribunals held at the U.S. base in Cuba.
The testy exchanges occurred during a hearing that was otherwise calm and orderly, in stark contrast to the chaotic 13-hour arraignment hearing in May, when defendants made defiant outbursts and refused to answer the judge's questions or listen through earphones to an Arabic-English translation of the proceedings. In those proceedings, one of the men was briefly restrained and two of them stood up to pray at one point.
Subsequent hearings had been pushed back for various reasons.
A hearing in July was postponed to allow the defendants to observe the holy month of Ramadan. Hearings in August were delayed when an Internet outage left the lawyers unable to access their electronic legal documents. That hearing was later canceled altogether as Tropical Storm Isaac approached. The storm caused no damage to the base.
A hearing scheduled for late September was also delayed because the work space for the defense lawyers was shut down due to a rat infestation and mold, which lawyers claimed were making them sick, Reuters reported.
Pohl ruled on Oct. 5 there would be no further postponements to the hearings.
An earlier attempt to the five men at Guantanamo ended when the Obama administration tried to move the trials to New York City, where two of the hijacked planes slammed into the World Trade Center.
That was abandoned under pressure from Congress and from New Yorkers, and the charges were re-filed in Guantanamo.
Reuters and?The Associated?Press?contributed to this report.?
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